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Zyloprim reduces serum and urinary uric acid concentrationsIts use should be individualized for each patient and requires an understanding of its mode of action and pharmacokineticssee CLINICAL PHARMACOLOGYCONTRAINDICATIONSWARNINGSand PRECAUTIONS

The action of Zyloprim differs from that of uricosuric agentswhich lower the serum uric acid level by increasing urinary excretion of uric acidZyloprim reduces both the serum and urinary uric acid levels by inhibiting the formation of uric acidThe use of Zyloprim to block the formation of urates avoids the hazard of increased renal excretion of uric acid posed by uricosuric drugs.

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficult breathingswelling of your facelipstongueor throat.

While adjusting the dosage of Zyloprim in patients who are being treated with colchicine and/or anti-inflammatory agentsit is wise to continue the latter therapy until serum uric acid has been normalized and there has been freedom from acute gouty attacks for several months.

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